The BelloCell is a disposable bioreactor capable of high density cell culture for protein expression, virus and monoclonal antibody production.

BelloCell is designed based on the concept of bellows-induced alteration flow of media and air through porous matrices, where cells reside and grow, providing a low shear, high aeration and foam free culture environment.

BelloCell bioreactor consists of two components : a sterile single-use culture BelloCell and a bellows compressor BelloStage

During usage, BelloCell bottle is partially filled with Media and inoculated with cells. The media are raised and lowered alternatively to submerge and expose the matrices, creating a dynamic interface between air and media on cell surface to maximize nutrient uptake and oxygen transfer.

Because of its high efficiency in nutrient and oxygen transfer, one BelloCell bottle, with specific surface area of 15,600 cm2 is capable of producing cell mass comparable to 20 – 30 roller bottles.

Since the Matrix is specially treated, belloCell can grow most anchorage dependent cells and allow easy harvest of whole cells, cell components or secreted proteins.

Features and Advantages : :: Pre-Sterile, ready to use, disposable :: Low shear stress, foam free, no O2 limitation :: Large surface area for high density cell culture :: Compatible with most serum free media :: Be able to collect whole cells or cell components .............................................................................................................. Applications : :: Mammalian and Insect cell lines :: Protein and Virus Production :: Monoclonal antibody production :: Proteome Research :: Drug Discovery :: Pharmacokinetics studies :: Gene and Cell Therapy

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System can be used in Batch / Semi-batch mode and also in Continuous culturing mode by changing a few accessories.

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