Fermenters and Bioreactors - Applikon Biotechnology, BV, Holland, since the last...35 Years !!

Mini Bioreactors: Real Small, Real bioreactors

The MiniBio range of bioreactors (250 ml, 500 ml and 1000 ml total volume) is a true scale down of the laboratory scale bioreactors in the 1 to 15 liter range.

The MiniBio systems have the same flexibility as the laboratory scale bioreactors. This means that the MiniBio systems can be customized to fit the demands of any process.

The small volume reduces medium costs and reduces the use expensive bench space.

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Photo Bioreactors

Photobioreactors from laboratory scale to production. State of the art Solid State Illumination system. All necessary controls of a standard bioreactor.

The illumination system is cool, long lasting and with programmable intensities.

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Single use Bioreactors

Single Use Bioreactors for real measurement and control

Single-Use bioreactors are increasingly favored for the economic advantages they offer. Many mammalian cell based biotech producers are moving to disposable modules, pre-sterilized and qualified according to regulatory requirements. Benefits of single-use bioreactors include faster facility set-up, reduction of down time, simplified validation, and more efficient use of plant floor space. Disposable bioreactors greatly reduce the risk of cross contamination in multi product facilities.

Applikon offers a selection of single-use bioreactors in two basic formats:

Flexible bag bioreactors
Rigid stirred tank bioreactors

Both bioreactor designs offer measurement and control of important process parameters.

The Appliflex flexible bag systems support both classical electrochemical sensor technology and optical sensors for pH and dissolved oxygen. Appliflex bioreactors are supplied in 10 liter, 20 liter and 50 liter total volume.

The CellReady bioreactor is a disposable version of the Applikon 3 liter glass autoclavable bioreactor and can be used as a direct replacement of these systems.

For both systems the standard controller is the Applikon ez-Control.

Real time measurement of pH, DO, T, agitation

Accurate control of pH, DO, T, agitation

Data logging & SCADA (21CFR part 11) available

Validatable system (total)

Standard available retrofit options: combination with 3rd party control systems

Qualified support and service

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Autoclavable Bioreactors

In the laboratory bioreactor range Applikon is worldwide market leader because of its dependable and easy to use systems. The bioreactors and fermentors excel in quality and modularity. An Applikon laboratory system is easy to upgrade if a change in research activities occurs.

Autoclavable glass bioreactors en fermentors ranging in size from 1 to 20 liters

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Steam in Place Bioreactors

The concept of modularity (using standard modules to customize the lay out of the bioreactor) has been extended to the stainless steel pilot plant bioreactors and fermentors. The vessels are cGMP and comply with different pressure codes throughout the world. The systems are fully documented and delivered with all necessary documentation to support easy validation.

The Biobench systems are available from 7 Liters - 20 Liters Total Volume

The Pilot Systems are divided in two types ranging in sizes of 20 to 140 liter

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Special Projects

All bioreactor systems more than 200 liters volume are considered as projects. Special care, emphasis, bioprocess conditions and more user interaction are considered during special projects.

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Sensors

Our own pH and DO (pO₂) sensors. The pO₂ sensors with special patented titanium module guarantees low drift in measurement and control.
Special retractable sensor holders - Trackfix - Sensors can be removed even from a running bioreactor. Can be used with both the pH sensor and the DO sensor.

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Alcohol Fermentation Monitor

The Alcohol Fermentation Monitor (AFM) is a robust and user-friendly laboratory parallel bioreactor that allows for accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic fermentations.

Monitoring the amount of CO_2(g) that evolves from a fermentation broth under well controlled conditions is a reliable comparison method that has proven to be very useful in all industries that use anaerobic fermentations. Because carbon dioxide production is stoichiometrically coupled with carbon source conversion, very useful metabolic data can be obtained.

The AFM provides very accurate standard measuring of CO_2(g) from six parallel fermentations that is both very low in maintenance and very easy to use.

Simple yet powerful-the perfect combination for a broad selection of applications.

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RAM Resonance Acoustic Mixer

Shaken Not Stirred

The RAM^® bench top biological mixer utilizes ResonantAcoustic^® technology that applies low-frequency, high-intensity acoustic energy to agitate microbial cultures. The RAM^® is a highly-efficient orbital-shaker replacement that dramatically enhances oxygenation and bulk mixing for bacterial and fungi cultures. Combined with the patented Oxy-Pump^® stopper, oxygen transfer rates up to 6-fold higher than orbital-shaken cultures can be achieved.

The RAM^® is an indispensible product for any cutting-edge biological laboratory.

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